On December 13, the Louisiana Department of Health (LDH) announced the detection of the first presumptive positive human case of highly pathogenic avian influenza (HPAI), or H5N1, in Louisiana. Following a report of increased mortality in the non-commercial backyard flock (non-poultry) on the property in southwest Louisiana, testing by Louisiana Animal Disease Diagnostic Laboratory (LADDL) has detected highly pathogenic avian influenza (HPAI) in the flock.